SCHEMBL11589892

SCHEMBL11589892

CNc1ccc2c(OC)cc(=O)n(C)c2n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 1/20 0.52
CYP19A1 P11511 6/20 0.46
NQO2 P16083 6/20 0.46
GLA P06280 2/20 0.46
ALDH1A1 P00352 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
KDM4E B2RXH2 1/20 0.46
GAA P10253 1/20 0.46
HPGD P15428 1/20 0.46
HSD17B10 Q99714 1/20 0.46
MAPT P10636 1/20 0.44
ACACA Q13085 1/20 0.39
BRD9 Q9H8M2 2/20 0.36
BRD7 Q9NPI1 2/20 0.36
CYP1A2 P05177 3/20 0.36
CYP3A4 P08684 2/20 0.35
MAPK1 P28482 1/20 0.35
BLM P54132 1/20 0.35
TSHR P16473 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11589595 0.80 NQO2 (0.44) ADORA1CYP19A1NQO2KDM4EGAA
SCHEMBL76177 0.77 KDM4E (0.56) ADORA1CYP19A1NQO2GLAALDH1A1
SCHEMBL29377253 0.77 KDM4E (0.56) ADORA1CYP19A1NQO2GLAALDH1A1
Perchlorate SCHEMBL30042407 0.70 KDM4E (0.49) ADORA1CYP19A1NQO2GLAALDH1A1
SCHEMBL11588815 0.69 NCF1 (0.34) ALDH1A1SMN1; SMN2KDM4EHSD17B10MAPT
SCHEMBL27185229 0.67 ACACA (0.46) ALDH1A1KDM4EHSD17B10MAPTACACA
SCHEMBL27185316 0.67 ALOX15 (0.48) ACACA
SCHEMBL11379787 0.65 KCNA3 (0.61) CYP19A1NQO2GLAALDH1A1SMN1; SMN2
SCHEMBL30783436 0.65 KCNA3 (0.61) CYP19A1NQO2GLAALDH1A1SMN1; SMN2
SCHEMBL27060737 0.65 NCF1 (0.65) NQO2ALDH1A1SMN1; SMN2KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4103257-A BLUE TO NEAR ULTRAVIOLET THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) 1978-07-25 US disclosed