SCHEMBL11591247

SCHEMBL11591247

Cc1cc(=O)n(C)c2nc(N(C)C)ccc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 6/20 0.44
KDM4E B2RXH2 3/20 0.44
CYP19A1 P11511 5/20 0.41
CRHR1 P34998 3/20 0.39
BRD9 Q9H8M2 2/20 0.39
BRD7 Q9NPI1 2/20 0.39
KAT2B Q92831 1/20 0.38
ALDH1A1 P00352 2/20 0.38
HPGD P15428 2/20 0.38
HSD17B10 Q99714 2/20 0.38
MAPT P10636 1/20 0.38
THRB P10828 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
DDB1 Q16531 1/20 0.38
CRBN Q96SW2 1/20 0.38
RXRA P19793 1/20 0.37
SMPD3 Q9NY59 2/20 0.37
ADORA2A P29274 1/20 0.37
ADORA1 P30542 1/20 0.37
GAA P10253 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11589606 0.83 ALDH1A1 (0.54) KDM4ECRHR1ALDH1A1HPGDHSD17B10
SCHEMBL76177 0.80 KDM4E (0.56) NQO2KDM4ECYP19A1BRD9BRD7
SCHEMBL29377253 0.80 KDM4E (0.56) NQO2KDM4ECYP19A1BRD9BRD7
SCHEMBL5701185 0.76 CDK4 (0.41) CRHR1BRD9KAT2BALDH1A1HPGD
SCHEMBL11589595 0.74 NQO2 (0.44) NQO2KDM4ECYP19A1BRD9BRD7
Perchlorate SCHEMBL30042407 0.74 KDM4E (0.49) NQO2KDM4ECYP19A1BRD9BRD7
SCHEMBL28428097 0.74 KDM4E (0.54) NQO2KDM4ECYP19A1ALDH1A1HPGD
SCHEMBL25703950 0.70 NQO2 (0.54) NQO2KDM4ECYP19A1ALDH1A1HPGD
SCHEMBL11583189 0.68 KMT2A (0.43) KDM4EALDH1A1HPGDHSD17B10MAPT
SCHEMBL15360079 0.66 SMPD3 (0.44) KDM4ECRHR1BRD9ALDH1A1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4103257-A BLUE TO NEAR ULTRAVIOLET THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) 1978-07-25 US claimed
US-4103257-A BLUE TO NEAR ULTRAVIOLET THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) 1978-07-25 US disclosed