Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.61 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | GUSB | P08236 | 1/20 | 0.56 |
| ▸ | TERT | O14746 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.52 |
| ▸ | IAPP | P10997 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL636137 | 0.90 | BACE1 (0.74) | BACE1NR1H4MAOBBCHEGUSB | |
| SCHEMBL7861935 | 0.84 | NR1H4 (0.74) | BACE1NR1H4MAOBCYP1A1CYP1B1 | |
| SCHEMBL471832 | 0.81 | BCHE (0.77) | BACE1NR1H4MAOBBCHEGUSB | |
| SCHEMBL9175439 | 0.81 | TYR (0.77) | BACE1CHRNA7TYRCAPN1CTSL | |
| SCHEMBL9175445 | 0.81 | TYR (0.77) | BACE1CHRNA7TYRCAPN1CTSL | |
| SCHEMBL30237661 | 0.79 | NR1H4 (0.67) | NR1H4MAOBCYP1A1CYP1B1CAPN1 | |
| SCHEMBL23610336 | 0.78 | TYR (0.64) | MAOBBCHECHRNA7CYP1B1TYR | |
| SCHEMBL471834 | 0.78 | TYR (0.64) | MAOBBCHECHRNA7CYP1B1TYR | |
| SCHEMBL27579527 | 0.78 | MAPT (0.77) | NR1H4MAOBBCHEGUSBCYP1B1 | |
| SCHEMBL11360766 | 0.78 | BACE1 (0.62) | BACE1NR1H4MAOBBCHEGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086400-A2 | SIRTUIN-ACTIVATING COMPOUNDS OF ENHANCED BIOAVAILABILITY | ISP INVESTMENTS INC. (US) | 2008-07-17 | — | — | WO | claimed |
| WO-2018045335-A1 | NITROGEN OXIDE DONORS AND USES THEREOF | NUSIRT SCIENCES, INC. (US) | 2018-03-08 | — | — | WO | disclosed |
| EP-3197437-A1 | COMPOSITIONS, METHODS AND KITS FOR TREATMENT OF DIABETES AND/OR HYPERLIPIDEMIA | NuSirt Sciences, Inc. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049236-A1 | COMPOSITIONS, METHODS AND KITS FOR TREATMENT OF DIABETES AND/OR HYPERLIPIDEMIA | NUSIRT SCIENCES, INC. (US) | 2016-03-31 | — | — | WO | disclosed |
| US-8475851-B2 | Preparations with wood extracts of locust trees | SYMRISE AG (DE) | 2013-07-02 | — | — | US | disclosed |
| US-20120195870-A1 | PREPARATIONS WITH WOOD EXTRACTS OF LOCUST TREES | SYMRISE AG (DE) | 2012-08-02 | — | — | US | disclosed |
| EP-2389922-A1 | Cyclohexyl carbamate compounds as anti-ageing actives | Symrise AG (DE) | 2011-11-30 | — | — | EP | disclosed |
| WO-2009132050-A9 | AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS | OTONOMY, INC. (US) | 2011-02-03 | — | — | WO | disclosed |
| US-7592436-B2 | Encoding polyphenoloxidases having activity that synthesizes aurones by using chalcones as substrates involved in the color of flowers such as snapdragons; can give yellow color to the flowers of plants by introducing into plants deficient in chalcone isomerase; snapdragons | INTERNATIONAL FLOWER DEVELOPMENTS PROPRIETARY LIMITED (AU) | 2009-09-22 | — | — | US | disclosed |
| WO-2008086400-A2 | SIRTUIN-ACTIVATING COMPOUNDS OF ENHANCED BIOAVAILABILITY | ISP INVESTMENTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| EP-1708689-A2 | COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS | The President and Fellows of Harvard College (US) | 2006-10-11 | — | — | EP | disclosed |
| EP-1001028-B1 | GENE ENCODING PROTEIN HAVING AURONE SYNTHESIZING ACTIVITY | SUNTORY LTD (JP) | 2006-05-31 | — | — | EP | disclosed |
| US-20060020123-A1 | Gene encoding a protein having aurone synthesis activity | SUNTORY FLOWERS LIMITED (JP) | 2006-01-26 | — | — | US | disclosed |
| US-6982325-B1 | Gene encoding protein having aurone synthesizing activity | SUNTORY FLOWERS LIMITED (JP) | 2006-01-03 | — | — | US | disclosed |
| WO-2005065667-A2 | COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-07-21 | — | — | WO | disclosed |
| US-6329189-B1 | FOR CATALYZING REACTION BETWEEN AN EPOXY RING OF AN EPOXYSUCCINIC ACID AND PHENOLIC HYDROXYL GROUP OF FLAVONOID, OR A FLAVONOID ANALOGOUS COMPOUND TO FORM TARTARIC ACID ETHER WHICH IS USED IN FOOD AND DRUG INDUSTRY | KIKKOMAN CORPORATION (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1001028-A1 | GENE ENCODING PROTEIN HAVING AURONE SYNTHESIZING ACTIVITY | SUNTORY LIMITED (JP) | 2000-05-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120195870-A1 | PREPARATIONS WITH WOOD EXTRACTS OF LOCUST TREES | LCT, CUTA, GLA | BACE1 1568/4885NR1H4 3765/4885MAOB 532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.