SCHEMBL1159966

SCHEMBL1159966

O=C1CC=C2CCC(=O)N12

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.34
CA12 O43570 2/20 0.33
CA1 P00915 2/20 0.33
CA9 Q16790 2/20 0.33
POLB P06746 1/20 0.33
CA2 P00918 1/20 0.32
TP53 P04637 1/20 0.32
HPGD P15428 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
RECQL P46063 1/20 0.31
KMT2A Q03164 2/20 0.31
RAF1 P04049 1/20 0.31
MAPK3 P27361 1/20 0.31
MAP3K8 P41279 1/20 0.31
MAP2K1 Q02750 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8574458 0.71 LMNA (0.35) LMNACA12CA1CA9POLB
SCHEMBL9622309 0.67 AR (0.31)
SCHEMBL8578338 0.62
SCHEMBL11478927 0.61 CA12 (0.67) LMNACA12CA1CA9POLB
SCHEMBL3247068 0.59
SCHEMBL11883244 0.59 L3MBTL1 (0.44) LMNACA12CA1CA9POLB
SCHEMBL6341570 0.58 TLR9 (0.52) CA12CA1CA9POLBTP53
SCHEMBL19680001 0.57 TSHR (0.37) CA12CA1CA9POLBCA2
SCHEMBL28376806 0.56 MGLL (0.42) LMNA
SCHEMBL370611 0.56 KMT2A (0.64) CA12CA1CA9POLBCA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250161264-A1 (AMPAR-PAM)-NMDA RECEPTOR ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF MENTAL CONDITIONS AND DISORDERS GILGAMESH PHARMACEUTICALS, INC. 2025-05-22 US claimed
WO-2023154450-A2 (AMPA-PAM)-NMDA RECEPTOR ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF MENTAL CONDITIONS AND DISORDERS GILGAMESH PHARMACEUTICALS, INC. (US) 2023-08-17 WO claimed
US-9125898-B2 Acetam derivatives for pain relief NEUROTUNE AG (CH) 2015-09-08 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
JP-2011513246-A 2011-04-28 JP claimed
CN-102014896-A Pharmaceutical composition comprising racetam and carnitine and process for its preparation BIOLAB SANUS FARMACEUTICA LTDA 2011-04-13 CN claimed
US-20110052556-A1 PHARMACEUTICAL COMPOSITION COMPRISING RACETAM AND CARNITINE AND PROCESS FOR ITS PREPARATION Biolab Sanus Farmaceutical Ltda (BR) 2011-03-03 US claimed
EP-2262495-A2 PHARMACEUTICAL COMPOSITION COMPRISING RACETAM AND CARNITINE AND PROCESS FOR ITS PREPARATION Biolab Sanus Farmacéutica Ltda (BR) 2010-12-22 EP claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
WO-2009105853-A2 PHARMACEUTICAL COMPOSITION BIOLAB SANUS FARMACEUTICA LTDA. (BR) 2009-09-03 WO claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-0759750-A4 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO HOWARD K (US) 1998-05-27 EP claimed
EP-0759750-A1 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO, Howard, K. (US) 1997-03-05 EP claimed
WO-1995031194-A1 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO HOWARD K (US) 1995-11-23 WO claimed
US-4663464-A Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione WARNER-LAMBERT COMPANY (US) 1987-05-05 US claimed
EP-0048132-B1 THE USE OF DIHYDRO-1H-PYRROLIZINE-3,5(2H,6H)-DIONE AS A COGNITION ACTIVATOR, PHARMACEUTICAL COMPOSITIONS CONTAINING THAT COMPOUND, AND THE PRODUCTION OF SUCH COMPOSITIONS WARNER-LAMBERT COMPANY (US) 1984-08-15 EP claimed
US-4372966-A TREATMENT OF SENILITY, ENHANCING MEMORY, REVERSAL OF AMNESIA CAUSED BY ELECTRIC SHOCK WARNER-LAMBERT COMPANY (US) 1983-02-08 US claimed
EP-0048132-A2 The use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator, pharmaceutical compositions containing that compound, and the production of such compositions WARNER-LAMBERT COMPANY (US) 1982-03-24 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250161264-A1 (AMPAR-PAM)-NMDA RECEPTOR ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF MENTAL CONDITIONS AND DISORDERS GRIN2A, GRIN1, GRIN3A LMNA 4093/4885CA12 4047/4885CA1 2801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.