Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17226609 | 0.84 | GRIN2D (0.48) | LMNAALDH1A1CA12CA2CA7 | |
| SCHEMBL26027255 | 0.80 | LMNA (0.36) | LMNAALDH1A1CA12CA2CA7 | |
| SCHEMBL1406851 | 0.73 | LMNA (0.36) | LMNAALDH1A1CA12CA2CA7 | |
| SCHEMBL28614932 | 0.73 | EPHX2 (0.54) | LMNAALDH1A1CA12CA2CA7 | |
| SCHEMBL1160739 | 0.73 | LMNA (0.36) | LMNAALDH1A1CA12CA2CA7 | |
| SCHEMBL13195555 | 0.73 | LMNA (0.36) | LMNAALDH1A1CA12CA2CA7 | |
| SCHEMBL1161114 | 0.71 | ALDH1A1 (0.43) | ALDH1A1CA2EPHX2SCN9AKMT2A | |
| SCHEMBL1222916 | 0.71 | HSD11B1 (0.34) | — | |
| SCHEMBL1032460 | 0.70 | EPHX1 (0.51) | EPHX2EPHX1MEN1KMT2A | |
| SCHEMBL13126731 | 0.70 | LMNA (0.34) | LMNAALDH1A1CA12CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459548-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011012800-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-02-03 | — | — | WO | disclosed |