Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19808496 | 0.87 | ALDH1A1 (0.53) | ALDH1A1HSD17B10TSHRSCN9AEPHX2 | |
| SCHEMBL1160886 | 0.77 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TSHRSCN9AEPHX2 | |
| Hydrochloric Acid SCHEMBL9948050 | 0.76 | ALDH1A1 (0.41) | ALDH1A1HSD17B10TSHRSCN9AEPHX2 | |
| SCHEMBL10131885 | 0.76 | ALDH1A1 (0.41) | ALDH1A1HSD17B10TSHRSCN9AEPHX2 | |
| SCHEMBL13766698 | 0.74 | ALDH1A1 (0.40) | ALDH1A1HSD17B10TSHRSCN9AEPHX2 | |
| SCHEMBL19808700 | 0.74 | ALDH1A1 (0.40) | ALDH1A1HSD17B10TSHRSCN9AEPHX2 | |
| SCHEMBL1160901 | 0.71 | LMNA (0.42) | ALDH1A1SCN9AEPHX2CA2KMT2A | |
| SCHEMBL9948713 | 0.71 | HSD11B1 (0.42) | ALDH1A1HSD17B10TSHREPHX2P2RX7 | |
| SCHEMBL1161055 | 0.70 | PKM (0.35) | ALDH1A1TSHRCA2KMT2A | |
| Hydrochloric Acid SCHEMBL9948049 | 0.70 | PKM (0.34) | ALDH1A1TSHRCA2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459548-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011012800-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-02-03 | — | — | WO | disclosed |