Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11611744 | 0.77 | GRN (0.43) | MAPTMEN1KMT2ALMNAHPGD | |
| SCHEMBL11464795 | 0.76 | NPBWR1 (0.41) | TP53MAPTKMT2ALMNAHPGD | |
| SCHEMBL11614807 | 0.74 | PTGDR2 (0.42) | TP53MAPTMEN1KMT2AGAA | |
| SCHEMBL11616738 | 0.72 | MAPK1 (0.45) | MAPTMEN1KMT2ALMNAHPGD | |
| SCHEMBL11619505 | 0.72 | POLB (0.42) | TP53MAPTMEN1KMT2ALMNA | |
| SCHEMBL11616869 | 0.71 | POLB (0.48) | TP53MAPTMEN1KMT2ALMNA | |
| SCHEMBL11612313 | 0.68 | HPGD (0.48) | MAPTMEN1KMT2ALMNAHPGD | |
| SCHEMBL11612175 | 0.67 | KMT2A (0.45) | MAPTMEN1KMT2AHPGDPOLB | |
| SCHEMBL27685830 | 0.67 | CYP1A2 (0.60) | MAPTMEN1KMT2ALMNAHIF1A | |
| SCHEMBL11614116 | 0.65 | PTGIR (0.44) | TP53LMNAHPGDSMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117145-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4117143-A | USED AS ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4113957-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |