Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11614960 | 0.78 | MAPT (0.42) | MAPTHTTKDM4EALDH1A1LMNA | |
| SCHEMBL11618645 | 0.75 | NPC1 (0.40) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL11613669 | 0.72 | NPC1 (0.42) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL11619227 | 0.72 | MAPT (0.53) | MAPTHTTKDM4EALDH1A1LMNA | |
| SCHEMBL11616262 | 0.70 | PTGDR2 (0.47) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL11611124 | 0.70 | NPC1 (0.47) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL11613839 | 0.69 | PLA2G4A (0.35) | MAPTKDM4EALDH1A1LMNAMAPK1 | |
| SCHEMBL11612919 | 0.69 | HDAC6 (0.39) | MAPTALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL11614849 | 0.68 | NPSR1 (0.49) | MAPTHTTALDH1A1LMNATP53 | |
| SCHEMBL11612313 | 0.67 | HPGD (0.48) | MAPTALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117145-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4117143-A | USED AS ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4113957-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |