Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11611744 | 0.81 | GRN (0.43) | SMN1; SMN2LMNAALDH1A1MAPTNPC1 | |
| SCHEMBL11612470 | 0.72 | MTNR1A (0.44) | MTNR1AMTNR1BLMNAALDH1A1MAPT | |
| SCHEMBL28785118 | 0.72 | ALDH1A1 (0.41) | SMN1; SMN2HTTHSD17B10LMNAALDH1A1 | |
| SCHEMBL11619251 | 0.69 | SLC22A12 (0.51) | TSHRLMNAALDH1A1MAPTTP53 | |
| SCHEMBL11611800 | 0.68 | PTGDR2 (0.45) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL11614313 | 0.68 | NPC1 (0.44) | SMN1; SMN2MTNR1AMTNR1BLMNAALDH1A1 | |
| SCHEMBL8896348 | 0.65 | MTNR1A (0.56) | SMN1; SMN2MTNR1AMTNR1BTSHRHTT | |
| SCHEMBL5187022 | 0.65 | MTNR1A (0.45) | SMN1; SMN2MTNR1AMTNR1BTSHRHSD17B10 | |
| SCHEMBL5257722 | 0.65 | SMN1; SMN2 (0.51) | SMN1; SMN2MTNR1AMTNR1BALDH1A1MAPT | |
| SCHEMBL5185595 | 0.62 | PTGES (0.60) | SMN1; SMN2LMNAGAATP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117145-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4117143-A | USED AS ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4113957-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |