Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11614681 | 0.81 | KDM4E (0.50) | GPR35KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL11615779 | 0.79 | KDM4E (0.45) | GPR35KDM4EPOLBPKMGLA | |
| SCHEMBL27730322 | 0.79 | MCL1 (0.62) | GPR35KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL11618317 | 0.79 | POLB (0.49) | KDM4EHSD17B10ALDH1A1POLBPKM | |
| SCHEMBL11615545 | 0.78 | GPR35 (0.45) | GPR35KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL11616595 | 0.78 | GPR35 (0.45) | GPR35KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL11617400 | 0.78 | GPR35 (0.45) | GPR35KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL11613152 | 0.76 | FABP4 (0.47) | KDM4EHSD17B10MCL1POLBPKM | |
| SCHEMBL11621960 | 0.76 | POLB (0.42) | GPR35KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL11613651 | 0.76 | KDM4E (0.46) | GPR35KDM4EHSD17B10POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4130649-A | Cyclohepta [B]pyridine-2-carboxylic acid derivatives | AYERST, MCKENNA & HARRISON LIMITED (CA) | 1978-12-19 | — | — | US | claimed |
| US-4118561-A | ANTIBACTERIAL, SYNERGISTIC, ANTI-CANCER ACTIVITY, ANTI-FOLIC ACID ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1978-10-03 | — | — | US | disclosed |