Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11623696 | 0.98 | HTR1A (0.51) | SIGMAR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL18402140 | 0.81 | SIGMAR1 (0.60) | SIGMAR1HTR1ADRD2DRD3LMNA | |
| SCHEMBL13457940 | 0.79 | SIGMAR1 (0.62) | SIGMAR1HTR1ADRD2DRD3LMNA | |
| SCHEMBL11549900 | 0.78 | SIGMAR1 (0.46) | SIGMAR1HTR1ALMNAMETAP1 | |
| SCHEMBL11549892 | 0.78 | SIGMAR1 (0.46) | SIGMAR1HTR1ALMNAMETAP1 | |
| SCHEMBL11549897 | 0.78 | SIGMAR1 (0.46) | SIGMAR1HTR1ALMNAMETAP1 | |
| SCHEMBL25379394 | 0.77 | PNMT (0.53) | SIGMAR1 | |
| SCHEMBL31263878 | 0.77 | PNMT (0.53) | SIGMAR1 | |
| SCHEMBL10741159 | 0.75 | HTR2A (0.50) | SIGMAR1HTR2ASLC6A3 | |
| SCHEMBL11620328 | 0.74 | CYP1A2 (0.38) | SIGMAR1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4127578-A | Diene intermediates for indantetrols | E. R. SQUIBB & SONS, INC. (US) | 1978-11-28 | — | — | US | disclosed |
| US-4092318-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1978-05-30 | — | — | US | disclosed |
| US-4044040-A | HYPERTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1977-08-23 | — | — | US | disclosed |