Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.41 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532907 | 0.82 | PTGS2 (0.50) | KIF11PTGS2 | |
| SCHEMBL11623789 | 0.80 | HPGD (0.43) | HPGD | |
| SCHEMBL11123090 | 0.77 | KIF11 (0.51) | KIF11PTGS2 | |
| SCHEMBL27731893 | 0.76 | NPBWR1 (0.44) | PTGS2HPGD | |
| SCHEMBL26093883 | 0.74 | KDM4E (0.44) | HPGD | |
| SCHEMBL8797359 | 0.74 | GFER (0.50) | KIF11HPGD | |
| SCHEMBL25250074 | 0.72 | KIF11 (0.43) | KIF11HPGD | |
| SCHEMBL11626212 | 0.72 | KIF11 (0.42) | KIF11HPGD | |
| SCHEMBL3095172 | 0.72 | HPGD (0.38) | PTGS2HPGD | |
| SCHEMBL27731900 | 0.72 | KDM4E (0.45) | PTGS2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4125530-A | FROM 1,1-DIHALO-3,3,3-TRIFLUOROACETONE, BASE, AMMONIA AND A CARBOXALDEHYDE | MERCK & CO., INC. (US) | 1978-11-14 | — | — | US | disclosed |
| US-4032522-A | ANTI-GOUT, ANTI-HYPERURICEMIC | MERCK & CO., INC. (US) | 1977-06-28 | — | — | US | disclosed |