SCHEMBL11633335

SCHEMBL11633335

CN1Cc2ccccc2Sc2ccccc2C1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.50
MAOB P27338 2/20 0.50
CYP2D6 P10635 3/20 0.47
CYP2C19 P33261 3/20 0.47
HTR1A P08908 2/20 0.47
DRD1 P21728 2/20 0.47
DRD3 P35462 2/20 0.47
CHRM2 P08172 1/20 0.47
ADRA2A P08913 1/20 0.47
ADORA3 P0DMS8 1/20 0.47
CHRM1 P11229 1/20 0.47
TBXA2R P21731 1/20 0.47
SLC6A2 P23975 1/20 0.47
SLC6A4 P31645 1/20 0.47
ADRA1A P35348 1/20 0.47
OPRM1 P35372 1/20 0.47
SLC6A3 Q01959 1/20 0.47
KCNH2 Q12809 1/20 0.47
SETD7 Q8WTS6 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11140336 0.85 MAOA (0.69) MAOAMAOBCYP2D6CYP2C19HTR1A
SCHEMBL11097250 0.80 DRD1 (0.59) MAOAMAOBCYP2D6CYP2C19HTR1A
SCHEMBL130712 0.80 MAOA (0.71) MAOAMAOBCYP2D6CYP2C19HTR1A
SCHEMBL17933519 0.79 MAOA (0.55) MAOACYP2D6CYP2C19HTR1ADRD1
SCHEMBL17933301 0.78 MAOA (0.47) MAOAMAOBCYP2D6CYP2C19HTR1A
SCHEMBL24964880 0.78 MAOA (0.68) MAOAMAOBCYP2D6CYP2C19DRD1
Bromide SCHEMBL2646357 0.78 MAOA (0.68) MAOAMAOBCYP2D6CYP2C19HTR1A
SCHEMBL19008228 0.76 ADRA2A (0.49) MAOAMAOBCYP2D6CYP2C19HTR1A
SCHEMBL8248175 0.75 RYR2 (0.57) MAOAMAOBCYP2D6CYP2C19HTR1A
SCHEMBL6677893 0.75 BRD4 (0.46) MAOAMAOBCYP2D6CYP2C19HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4123555-A Sulfide compounds and methods and compositions for treating depression BURROUGHS WELLCOME CO. (US) 1978-10-31 US disclosed
US-4103020-A Sulfide compounds as antidepressants BURROUGHS WELLCOME CO. (US) 1978-07-25 US disclosed
US-4095027-A ANTIDEPRESSANTS BURROUGHS WELLCOME CO. (US) 1978-06-13 US disclosed
US-4091100-A HYDROXY- AND AMINO-SUBSTITUTED DIPHENYL SULFIDES, ANTIDEPRESSANTS BURROUGHS WELLCOME CO. (US) 1978-05-23 US disclosed
US-4061863-A ANTIDEPRESSANT BURROUGHS WELLCOME CO. (US) 1977-12-06 US disclosed
US-4056632-A ANTIDEPRESSANT BURROUGHS WELLCOME CO. (US) 1977-11-01 US disclosed
US-4044014-A ANTIDEPRESSANT BURROUGHS WELLCOME CO. (US) 1977-08-23 US disclosed
US-3997540-A ANTIDEPRESSANT BURROUGHS WELLCOME CO. (US) 1976-12-14 US disclosed