Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11638545 | 0.91 | L3MBTL1 (0.33) | HSD17B10 | |
| Maleic Acid SCHEMBL11635484 | 0.80 | MAPT (0.40) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL21314143 | 0.72 | CA1 (0.55) | LMNASMN1; SMN2CA1CA2NFKB1 | |
| Maleic Acid SCHEMBL11635543 | 0.71 | SMN1; SMN2 (0.39) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| Maleic Acid SCHEMBL11635392 | 0.71 | CA12 (0.44) | LMNACA2MAPTKDM4EALDH1A1 | |
| SCHEMBL11638543 | 0.69 | GAA (0.42) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL11638550 | 0.69 | GAA (0.42) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL11875368 | 0.68 | GRIN1 (0.49) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL11882884 | 0.68 | GRIN2D (0.50) | LMNASMN1; SMN2ALDH1A1MEN1POLB | |
| SCHEMBL1158588 | 0.66 | LMNA (0.43) | LMNASMN1; SMN2CA1CA2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4109008-A | SUBSTITUTED WITH AN AMIDINO AND A 1,3-DIMETHYL-2-OXO-BENZIMIDAZOL- 5-YL RADICAL | HEXACHIMIE (FR) | 1978-08-22 | — | — | US | disclosed |