Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14544564 | 0.83 | SMN1; SMN2 (0.43) | FOLH1TSHRCYP4F2CYP4A11TRPA1 | |
| SCHEMBL12235278 | 0.81 | TDP1 (0.48) | TSHRTRPA1ALDH1A1MAPK1GSK3B | |
| SCHEMBL28201097 | 0.81 | LOXL2 (0.59) | FOLH1TSHRCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL924897 | 0.81 | CYP4F2 (0.49) | FOLH1CYP4F2CYP4A11LOXL2 | |
| SCHEMBL39676 | 0.80 | TSHR (0.47) | FOLH1TSHRCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL46680 | 0.80 | FOLH1 (0.66) | FOLH1HIF1ACA1CA2 | |
| SCHEMBL28410476 | 0.80 | FOLH1 (0.46) | FOLH1TSHRCYP4F2CYP4A11MAPK1 | |
| SCHEMBL29472003 | 0.80 | TSHR (0.47) | FOLH1TSHRCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL11109822 | 0.79 | NPC1 (0.50) | FOLH1CYP4F2CYP4A11FFAR4 | |
| SCHEMBL185773 | 0.78 | PARP1 (0.57) | FOLH1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106117174-A | Flavone acetic acid analog derivative, its pharmaceutical composition, Preparation Method And The Use | 中国人民解放军军事医学科学院毒物药物研究所 | 2016-11-16 | — | — | CN | disclosed |
| CN-101365446-B | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery via implantable medical devices | RESVERLOGIX CORP | 2013-05-22 | — | — | CN | disclosed |
| CN-101365446-A | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery via implantable medical devices | RESVERLOGIX CORP (CA) | 2009-02-11 | — | — | CN | disclosed |
| CN-1110685-A | Nitrogen-containing spiro ring | MERCK & CO INC (US) | 1995-10-25 | — | — | CN | disclosed |
| CN-1053613-A | Nitrogen-containing spiro ring | MERCK & CO INC (US) | 1991-08-07 | — | — | CN | disclosed |
| US-4122200-A | 6',2-(2'Arylchromonyl) propionic acids, and analgesic and anti-inflammatory derivatives thereof | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1978-10-24 | — | — | US | disclosed |
| US-4097582-A | 6',2-(2'-Arylchromonyl) propionic acids, and analgesic and anti-inflammatory derivatives thereof | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1978-06-27 | — | — | US | disclosed |