SCHEMBL1163564

SCHEMBL1163564

COC(=O)[C@@H](NC(=O)OC(C(=O)OC(C)(C)C)c1ccccc1)C1CC2CCC(C1)N2C(=O)OCc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 1/20 0.41
AGTR2 P50052 6/20 0.39
CYP3A4 P08684 5/20 0.38
TSHR P16473 5/20 0.38
CYP2C9 P11712 4/20 0.38
CYP2C19 P33261 4/20 0.38
CYP1A2 P05177 3/20 0.38
ALDH1A1 P00352 3/20 0.38
KMT2A Q03164 2/20 0.38
POLB P06746 1/20 0.38
CYP2D6 P10635 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
LMNA P02545 2/20 0.38
MEN1 O00255 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAPK1 P28482 1/20 0.38
HSD17B10 Q99714 1/20 0.38
KLK7 P49862 1/20 0.37
KLK5 Q9Y337 1/20 0.37
YAP1 P46937 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3744365 0.89 CTSL (0.50) CTSLAGTR2KMT2AL3MBTL1SMN1; SMN2
SCHEMBL3748764 0.89 CTSL (0.50) CTSLAGTR2KMT2AL3MBTL1SMN1; SMN2
SCHEMBL1163483 0.84 CYP3A4 (0.47) CYP3A4TSHRCYP2C9CYP2C19CYP1A2
SCHEMBL6880634 0.83 CTSL (0.51) CTSLAGTR2KMT2AL3MBTL1MAPK1
SCHEMBL11902313 0.83 CTSL (0.51) CTSLAGTR2KMT2AL3MBTL1MAPK1
SCHEMBL1163671 0.82 CTSL (0.49) CTSLAGTR2KMT2AL3MBTL1KLK7
SCHEMBL6882544 0.77 AGTR2 (0.43) AGTR2CYP3A4TSHRCYP2C9CYP2C19
SCHEMBL11901994 0.77 ALDH1A1 (0.46) AGTR2CYP3A4TSHRCYP2C9CYP2C19
SCHEMBL21653658 0.77 KMT2A (0.62) CTSLAGTR2TSHRALDH1A1KMT2A
SCHEMBL21653773 0.77 KMT2A (0.62) CTSLAGTR2TSHRALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011018796-A1 AN IMPROVED PROCESS FOR THE SYNTHESIS OF ALKYL/ARALKYL (2S)-2-(TERT-BUTOXYCARBONYL)-AMINO-2-[-8-AZABICYCLO[3.2.1]OCT-3-YL]-EXO-ACETATE AND ANALOGS THEREOF: KEY INTERMEDIATES FOR THE PREPARATION OF DPPIV INHIBITORS LUPIN LIMITED (IN) 2011-02-17 WO disclosed