Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | MEN1 | O00255 | 5/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | CRHBP | P24387 | 1/20 | 0.62 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.62 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.55 |
| ▸ | TUBB | P07437 | 1/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.55 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.55 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426349 | 1.00 | MAPT (0.68) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL1165671 | 1.00 | MAPT (0.68) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL8932220 | 1.00 | MAPT (0.68) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL7443327 | 1.00 | MAPT (0.68) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL1869047 | 1.00 | MAPT (0.68) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL5472460 | 0.82 | DHFR (0.79) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL5472464 | 0.82 | DHFR (0.79) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL13848400 | 0.81 | MAPT (1.00) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL7438862 | 0.81 | MAPT (0.61) | MAPTMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL7438873 | 0.81 | MAPT (0.61) | MAPTMEN1KMT2AKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003096-B2 | Means and methods for the recruitment and identification of stem cells | VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW (BE) | 2011-08-23 | — | — | US | claimed |
| EP-0563798-B1 | Butadiene derivatives, their preparation and use as an antithrombotic agent | TANABE SEIYAKU CO (JP) | 1997-06-11 | — | — | EP | claimed |
| EP-0563798-A1 | Butadiene derivatives, their preparation and use as an antithrombotic agent | TANABE SEIYAKU CO., LTD. (JP) | 1993-10-06 | — | — | EP | claimed |
| JP-7149642-A | — | — | None | — | — | JP | disclosed |
| US-10781180-B2 | 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2020-09-22 | — | — | US | disclosed |
| US-20200247755-A1 | ETHERS, SECONDARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2020-08-06 | — | — | US | disclosed |
| US-10450276-B2 | Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-20190263757-A1 | 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2019-08-29 | — | — | US | disclosed |
| US-20190070149-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2019-03-07 | — | — | US | disclosed |
| EP-3395816-A1 | ETHERS, SECONDARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2018-10-31 | — | — | EP | disclosed |
| US-9987252-B2 | Primary amines and derivitves thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2018-06-05 | — | — | US | disclosed |
| EP-0889879-B1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-6248743-B1 | ANTITHROMBOTIC AGENTS EFFECTIVE TO INHIBIT THE PRODUCTION OF TYPE 1 PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) | TANABE SEIYAKU CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| EP-0889879-A1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036864-A1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1997-10-09 | — | — | WO | disclosed |
| US-5639789-A | ANTITHROMBOTIC DRUGS | TANABE SEIYAKU CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0563798-B1 | Butadiene derivatives, their preparation and use as an antithrombotic agent | TANABE SEIYAKU CO (JP) | 1997-06-11 | — | — | EP | disclosed |
| US-5514815-A | ANTITHROMBOTIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1996-05-07 | — | — | US | disclosed |
| JP-H07149642-A | ANTITHROMBOTIC MEDICINE | TANABE SEIYAKU CO LTD | 1995-06-13 | — | — | JP | disclosed |
| EP-0563798-A1 | Butadiene derivatives, their preparation and use as an antithrombotic agent | TANABE SEIYAKU CO., LTD. (JP) | 1993-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190070149-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HTR5A, HTR2A, HTR1A | MAPT 539/4885MEN1 3346/4885KMT2A 799/4885 |
| US-20190263757-A1 | 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HTR5A, HTR3A, HTR2A | MAPT 666/4885MEN1 4384/4885KMT2A 1293/4885 |
| US-10450276-B2 | Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | HTR2A, HTR5A, HTR2C | MAPT 624/4885MEN1 4024/4885KMT2A 480/4885 |
| US-20200247755-A1 | ETHERS, SECONDARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HTR2A, HTR5A, HTR2C | MAPT 624/4885MEN1 4024/4885KMT2A 480/4885 |
| US-10781180-B2 | 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | HTR5A, HTR3A, HTR2A | MAPT 666/4885MEN1 4384/4885KMT2A 1293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.