Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzo[D]Thiazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzo[D]Thiazole SCHEMBL10587301 | 0.90 | ALDH1A1 (0.73) | ALDH1A1HSD17B10NPC1RAB9AKDM4E | |
| Benzo[D]Thiazole SCHEMBL2565700 | 0.90 | ALDH1A1 (0.73) | ALDH1A1HSD17B10NPC1RAB9AKDM4E | |
| Benzo[D]Thiazole SCHEMBL2173015 | 0.89 | ALDH1A1 (0.95) | ALDH1A1HSD17B10NPC1RAB9AKDM4E | |
| Benzo[D]Thiazole SCHEMBL27701795 | 0.88 | ALDH1A1 (0.76) | ALDH1A1HSD17B10NPC1RAB9AKDM4E | |
| Benzo[D]Thiazole SCHEMBL27590650 | 0.88 | ALDH1A1 (0.76) | ALDH1A1HSD17B10NPC1RAB9AKDM4E | |
| Benzo[D]Thiazole SCHEMBL28333163 | 0.88 | ALDH1A1 (0.76) | ALDH1A1HSD17B10NPC1RAB9AKDM4E | |
| Benzo[D]Thiazole SCHEMBL27931731 | 0.88 | ALDH1A1 (0.76) | ALDH1A1HSD17B10NPC1RAB9AKDM4E | |
| Benzo[D]Thiazole SCHEMBL10847268 | 0.87 | — | — | |
| Benzo[D]Thiazole SCHEMBL451685 | 0.87 | — | — | |
| Benzo[D]Thiazole SCHEMBL8430 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103228643-B | As the benzoxazole derivative of histamine h 4 receptor part | BIOPROJET (FR) | 2015-11-25 | — | — | CN | disclosed |
| CN-103228643-A | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET SOC CIV | 2013-07-31 | — | — | CN | disclosed |
| CN-1143364-A | 5-HT3 receptor agonist, novel thiazole derivative, and intermediate thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1997-02-19 | — | — | CN | disclosed |
| US-4028323-A | WITH A SUBSTITUTED AMINOBENZENE | CIBA-GEIGY AG (CH) | 1977-06-07 | — | — | US | disclosed |