SCHEMBL11705856

SCHEMBL11705856

CC1(O)CCc2cc(O)ccc2O1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 1/20 0.55
ENTPD5 O75356 2/20 0.42
ESR1 P03372 4/20 0.42
ESR2 Q92731 4/20 0.42
RXRA P19793 1/20 0.41
MAPT P10636 1/20 0.41
CETP P11597 1/20 0.40
PTPN1 P18031 2/20 0.40
MGAM O43451 4/20 0.39
GAA P10253 4/20 0.39
SI P14410 4/20 0.39
MGAM2 Q2M2H8 4/20 0.39
PTGS1 P23219 1/20 0.37
PTGS2 P35354 1/20 0.37
XDH P47989 1/20 0.37
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HIF1A Q16665 1/20 0.37
EPAS1 Q99814 1/20 0.37
CYP3A4 P08684 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30513267 0.84 AKT1 (0.56) AKT1ENTPD5ESR1ESR2MAPT
SCHEMBL3184205 0.84 AKT1 (0.56) AKT1ENTPD5ESR1ESR2MAPT
SCHEMBL7787622 0.84 AKT1 (0.51) AKT1ENTPD5ESR1ESR2RXRA
SCHEMBL9749407 0.79 AKT1 (0.51) AKT1ENTPD5ESR1ESR2RXRA
SCHEMBL8653315 0.78 AKT1 (0.50) AKT1RXRAPTPN1MGAMGAA
SCHEMBL11343263 0.78 AKT1 (0.50) AKT1ENTPD5ESR1ESR2MAPT
SCHEMBL4475359 0.77 AKT1 (0.49) AKT1ENTPD5ESR1ESR2CETP
SCHEMBL21346943 0.77 AKT1 (0.46) AKT1ENTPD5ESR1ESR2RXRA
SCHEMBL4152628 0.77 SIGMAR1 (0.43) AKT1RXRAPTGS1PTGS2ALDH1A1
SCHEMBL13005003 0.76 AKT1 (0.48) AKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4026907-A INTERMEDIATES FOR ALPHA-TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-05-31 US disclosed
US-4018799-A INTERMEDIATES FOR TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-04-19 US disclosed
US-4003919-A INTERMEDIATES FOR ALPHA-TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-01-18 US disclosed
US-3947473-A (6-HYDROXY-CHROMAN-2-YL) CARBOXYLIC ACID DERIVATIVES HOFFMAN-LA ROCHE INC. (US) 1976-03-30 US disclosed