Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19714100 | 0.88 | LMNA (0.73) | CYP1A2CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL17824292 | 0.87 | MEN1 (0.64) | CYP1A2CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL19713883 | 0.83 | MEN1 (0.79) | CYP1A2CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL20715535 | 0.83 | LMNA (0.57) | CYP1A2CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL19714470 | 0.82 | ALDH1A1 (0.56) | CYP1A2CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL1170660 | 0.82 | ALDH1A1 (0.86) | CYP1A2CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL19714456 | 0.81 | MEN1 (0.54) | CYP1A2CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL17824280 | 0.81 | LMNA (0.61) | CYP1A2CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL19714641 | 0.81 | ALDH1A1 (0.63) | CYP1A2CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL17833386 | 0.81 | LMNA (0.61) | CYP1A2CYP2C19CYP3A4CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362184-A1 | PRO-SURVIVAL COMPOUNDS | HERIOT-WATT UNIVERSITY (GB) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362184-A1 | PRO-SURVIVAL COMPOUNDS | MCL1, MKI67, MORF4L1 | CYP1A2 4708/4885CYP2C19 4860/4885CYP3A4 4779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.