Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1487077 | 0.96 | CA12 (0.47) | ALDH1A1KDM4ECA12CA9GAA | |
| SCHEMBL511774 | 0.77 | CA1 (0.50) | ALDH1A1KDM4EGAATSHRMEN1 | |
| SCHEMBL8731415 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KDM4ECA12CA9GAA | |
| SCHEMBL5089061 | 0.77 | GAA (0.45) | ALDH1A1KDM4EGAATSHRPOLB | |
| SCHEMBL11708793 | 0.75 | CA1 (0.49) | ALDH1A1KDM4EGAATSHRMEN1 | |
| SCHEMBL1487076 | 0.75 | CA1 (0.49) | ALDH1A1KDM4EGAATSHRMEN1 | |
| SCHEMBL7672294 | 0.75 | CA9 (0.43) | CA12CA9MEN1KMT2AATM | |
| SCHEMBL16646001 | 0.72 | GAA (0.41) | ALDH1A1KDM4EGAATSHRPOLB | |
| SCHEMBL14158412 | 0.72 | ALDH1A1 (0.41) | ALDH1A1KDM4ECA12CA9GAA | |
| SCHEMBL21334358 | 0.72 | GAA (0.41) | ALDH1A1KDM4ECA12CA9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4035381-A | AMPICILLIN, AMOXICILLIN, 5-FORMYL-2-FURANSULFONIC ACID | BRISTOL-MYERS COMPANY (US) | 1977-07-12 | — | — | US | disclosed |