Piperazine

Piperazine

SCHEMBL1171029

C1CNCCN1.CCS(=O)(=O)O.CCS(=O)(=O)O

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ESR1

The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.42
LMNA P02545 2/20 0.42
CYP3A4 P08684 1/20 0.42
GABRA1 P14867 1/20 0.42
GABRG2 P18507 1/20 0.42
NFKB1 P19838 1/20 0.42
GABRB3 P28472 1/20 0.42
GABRA5 P31644 1/20 0.42
GABRA3 P34903 1/20 0.42
GABRA2 P47869 1/20 0.42
GABRA6 Q16445 1/20 0.42
PDE4A P27815 2/20 0.38
HIF1A Q16665 1/20 0.38
MAPT P10636 1/20 0.38
KDR P35968 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
ALDH1A1 P00352 1/20 0.37
CXCR4 P61073 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Piperazine SCHEMBL572783 1.00 TSHR (0.42) TSHRLMNACYP3A4GABRA1GABRG2
Piperazine SCHEMBL28176112 1.00 TSHR (0.42) TSHRLMNACYP3A4GABRA1GABRG2
Piperazine SCHEMBL28092993 0.97 TSHR (0.40) TSHRLMNACYP3A4GABRA1GABRG2
Piperazine SCHEMBL4195986 0.87 LMNA (0.34) TSHRLMNACYP3A4GABRA1GABRG2
Piperidine SCHEMBL4297330 0.86 ALDH1A1 (0.47) TSHRLMNACYP3A4GABRA1GABRG2
Piperazine SCHEMBL8991321 0.84 TSHR (0.42) TSHRLMNACYP3A4GABRA1GABRG2
Piperazine SCHEMBL28369178 0.82 TSHR (0.39) TSHRLMNACYP3A4GABRA1GABRG2
Morpholine SCHEMBL668275 0.82 MEN1 (0.50) TSHRLMNACYP3A4GABRA1GABRG2
Piperazine SCHEMBL28077828 0.82 TSHR (0.41) TSHRLMNACYP3A4GABRA1GABRG2
Piperazine SCHEMBL28134580 0.81 LMNA (0.43) TSHRLMNACYP3A4GABRA1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060073163-A1 Anti-sepsis conjugate vaccine ENDOBIOLOGICS, INCORPORATED. 2006-04-06 US claimed
WO-2024014512-A1 LYOPHILIZED COMPOSITION OF NUCLEIC-ACID-LOADED LIPID NANOPARTICLES 日油株式会社 2024-01-18 WO disclosed
WO-2023000247-A1 APPLICATION OF α-ASARONE IN PREPARATION OF MEDICINE FOR PREVENTING OR TREATING HEMORRHAGIC STROKE 四川大学 2023-01-26 WO disclosed
CN-115397340-A Microstructure hemostat BVW控股公司 2022-11-25 CN disclosed
WO-2022048197-A1 USE OF α-ASARONE IN PREPARATION OF DRUG FOR PREVENTION OR TREATMENT OF CEREBRAL ISCHEMIC STROKE 四川大学 2022-03-10 WO disclosed
EP-3761030-A1 METHOD FOR STABILIZING PROTEIN CONTAINED IN SAMPLE AND SOLUTION FOR STABILIZING PROTEIN CONTAINED IN SAMPLE EIKEN KAGAKU KABUSHIKI KAISHA (JP) 2021-01-06 EP disclosed
US-20200407425-A1 METHOD OF STABILIZING PROTEIN CONTAINED IN SPECIMEN AND SOLUTION FOR STABILIZING PROTEIN CONTAINED IN SPECIMEN EIKEN KAGAKU KABUSHIKI KAISHA (JP) 2020-12-31 US disclosed
US-20200377572-A1 METHOD FOR STABILIZING HEMOGLOBIN-HAPTOGLOBIN COMPLEX AND A PRESERVATION SOLUTION FOR PRESERVING SPECIMENS CONTAINING HEMOGLOBIN EIKEN KAGAKU KABUSHIKI KAISHA (JP) 2020-12-03 US disclosed
US-10828608-B2 Semipermeable membrane and preparation method thereof ZHEJIANG UNIVERSITY (CN) 2020-11-10 US disclosed
EP-3719496-A1 METHOD FOR STABILIZING COMPLEX OF HEMOGLOBIN AND HAPTOGLOBIN AND A PRESERVATION SOLUTION FOR PRESERVING SPECIMENS CONTAINING HEMOGLOBIN Eiken Kagaku Kabushiki Kaisha (JP) 2020-10-07 EP disclosed
US-5340735-A Genetic engineering COGNIS, INC. (US) 1994-08-23 US disclosed
WO-1994004562-A9 MAMMALIAN GAP-43 COMPOSITIONS AND METHODS OF USE 1994-04-14 WO disclosed
WO-1994004562-A1 MAMMALIAN GAP-43 COMPOSITIONS AND METHODS OF USE THE GENERAL HOSPITAL CORPORATION (US) 1994-03-03 WO disclosed
EP-0580649-A1 PLANT PROMOTER INVOLVED IN CONTROLLING LIPID BIOSYNTHESIS IN SEEDS UNILEVER PLC (GB) 1994-02-02 EP disclosed
US-5221615-A Colorimetric, quantitative analysis using sorbitol, gelatin or ammonium sulfate buffers Modrovich, Ivan E. (US) 1993-06-22 US disclosed
WO-1992018634-A1 PLANT PROMOTER INVOLVED IN CONTROLLING LIPID BIOSYNTHESIS IN SEEDS UNILEVER PLC (GB) 1992-10-29 WO disclosed
WO-1992018138-A1 MAMMALIAN GAP-43 COMPOSITIONS AND METHODS OF USE THE GENERAL HOSPITAL CORPORATION (US) 1992-10-29 WO disclosed
EP-0407543-A4 MAMMALIAN GAP-43 COMPOSITIONS AND METHODS OF USE 1992-10-14 EP disclosed
EP-0407543-A1 MAMMALIAN GAP-43 COMPOSITIONS AND METHODS OF USE THE GENERAL HOSPITAL CORPORATION (US) 1991-01-16 EP disclosed
WO-1990006948-A1 MAMMALIAN GAP-43 COMPOSITIONS AND METHODS OF USE FISHMAN MARK C (US) 1990-06-28 WO disclosed