Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL1171029 | 1.00 | TSHR (0.42) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Piperazine SCHEMBL28176112 | 1.00 | TSHR (0.42) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Piperazine SCHEMBL28092993 | 0.97 | TSHR (0.40) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Piperazine SCHEMBL4195986 | 0.87 | LMNA (0.34) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Piperidine SCHEMBL4297330 | 0.86 | ALDH1A1 (0.47) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Piperazine SCHEMBL8991321 | 0.84 | TSHR (0.42) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Piperazine SCHEMBL28369178 | 0.82 | TSHR (0.39) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Morpholine SCHEMBL668275 | 0.82 | MEN1 (0.50) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Piperazine SCHEMBL28077828 | 0.82 | TSHR (0.41) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Piperazine SCHEMBL28134580 | 0.81 | LMNA (0.43) | TSHRLMNACYP3A4GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 439 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399274-A1 | METHOD OF HARVESTING BIOLOGICS | Solventum Intellectual Properties Company (US) | 2024-07-17 | — | — | EP | claimed |
| CN-118258660-A | Method for detecting immunogenicity of protein medicine | 上海益诺思生物技术股份有限公司 | 2024-06-28 | — | — | CN | claimed |
| CN-118226022-A | Dextran latex enhanced turbidimetry detection kit | 广东省科学院生物与医学工程研究所 | 2024-06-21 | — | — | CN | claimed |
| CN-113533282-B | Biotin quantitative determination method based on homogeneous phase time-resolved fluorescence | 中国科学院苏州生物医学工程技术研究所 | 2024-05-28 | — | — | CN | claimed |
| CN-117942617-A | Polyethylene glycol hydrogel monolithic column and method for separating and purifying extracellular vesicles in batches | 陕西师范大学 | 2024-04-30 | — | — | CN | claimed |
| CN-117918334-A | Tumor cell stabilizing solution and preparation method and application thereof | 苏州莱博睿思生物科技有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-117736977-A | Sperm micromanipulation liquid and preparation method and application thereof | 瑞柏生物（中国）股份有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-117398481-A | Drug screening method based on breast cancer organoid and organoid transplantation tumor mouse model | 零壹人工智能科技研究院(南京)有限公司 | 2024-01-16 | — | — | CN | claimed |
| CN-113092784-B | One-step capturing method and application of macromolecules by adopting functionalized magnetic beads to carry out bio-orthogonal chemistry | 中国科学院深圳先进技术研究院 | 2023-09-08 | — | — | CN | claimed |
| CN-112661987-B | Functionalized DNA hydrogel, preparation method and application thereof | 中国科学院苏州纳米技术与纳米仿生研究所 | 2023-08-22 | — | — | CN | claimed |
| CN-105842317-A | pH-regulated dual-enzyme electrochemical biosensor and preparation method thereof | 宁夏医科大学 | 2016-08-10 | — | — | CN | claimed |
| CN-104459103-B | The preparation method of D-dimer quality control product | INSTITUTE OF BLOOD TRANSFUSION, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2016-04-27 | — | — | CN | claimed |
| CN-105462909-A | Culture method for high-efficiency human follicle stimulating hormone expression CHO cells | HARBIN PHARMACEUTICAL GROUP TECH CENTER | 2016-04-06 | — | — | CN | claimed |
| CN-104862384-A | Method for screening protein capable of interacting with promoter | UNIV FUJIAN | 2015-08-26 | — | — | CN | claimed |
| CN-104459103-A | Preparation method of D-dimer quality controls | INST OF BLOOD TRANSFUSION CHINESE ACADEMY OF MEDICAL SCIENCES | 2015-03-25 | — | — | CN | claimed |
| CN-102628064-B | Method for increasing yield of phellinus linteus total triterpene compound | INST AGRI RESOURCES CAAS | 2013-12-04 | — | — | CN | claimed |
| CN-102105790-A | Enhanced immunoassay sensor | UNIV BIOSENSORS PTY LTD | 2011-06-22 | — | — | CN | claimed |
| CN-101570741-A | Method and combined medium for preparing insulin-like secreting cells | UNIV ZHEJIANG (CN) | 2009-11-04 | — | — | CN | claimed |
| CN-1242935-C | Culturing method of microbe for high temperature waste water biochemical treatment | CHINA PETROLEUM & CHEMICAL (CN) | 2006-02-22 | — | — | CN | claimed |
| CN-1597569-A | Culturing method of microbe for high temperature waste water biochemical treatment | CHINA PETROCHEMICAL CO LTD (CN) | 2005-03-23 | — | — | CN | claimed |