Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11479740 | 0.75 | PTGES (0.73) | PTGESMAPTTP53PTGS2LMNA | |
| SCHEMBL11243005 | 0.74 | NPSR1 (0.58) | PTGESMAPTTP53LMNAALDH1A1 | |
| SCHEMBL11466884 | 0.73 | PTGES (0.41) | PTGESMAPTTP53PTGS2LMNA | |
| SCHEMBL11467766 | 0.71 | TP53 (0.59) | PTGESMAPTTP53PTGS2LMNA | |
| SCHEMBL11873100 | 0.71 | MAP4K4 (0.40) | CYP1A2CYP2C9CYP2C19MAPTTP53 | |
| SCHEMBL12603806 | 0.70 | POLB (0.52) | CYP1A2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL11467226 | 0.70 | NPSR1 (0.47) | PTGESMAPTLMNAALDH1A1RAB9A | |
| SCHEMBL10814630 | 0.69 | NPSR1 (0.64) | PTGESMAPTTP53LMNAALDH1A1 | |
| SCHEMBL11474297 | 0.69 | PTGES (0.36) | PTGESCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL805120 | 0.68 | POLB (0.57) | CYP1A2CYP3A4CYP2C9CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4018923-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |
| US-4013654-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1977-03-22 | — | — | US | disclosed |