Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11477119 | 0.85 | PTGES (1.00) | PTGESMAPTPTGS2TP53 | |
| SCHEMBL11485827 | 0.84 | PTGES (0.79) | PTGESMAPTPTGS2LMNATP53 | |
| SCHEMBL11240834 | 0.82 | PTGES (0.90) | PTGESMAPTPTGS2LMNATP53 | |
| SCHEMBL11243005 | 0.78 | NPSR1 (0.58) | PTGESMAPTLMNATP53 | |
| SCHEMBL11475303 | 0.78 | PTGES (0.67) | PTGESMAPTLMNATP53 | |
| SCHEMBL11467766 | 0.78 | TP53 (0.59) | PTGESMAPTPTGS2LMNATP53 | |
| SCHEMBL11482987 | 0.77 | GPR84 (0.62) | PTGESMAPTTP53 | |
| SCHEMBL11467226 | 0.77 | NPSR1 (0.47) | PTGESMAPTLMNA | |
| SCHEMBL11244831 | 0.76 | PTGES (0.80) | PTGESMAPTPTGS2LMNATP53 | |
| SCHEMBL31582268 | 0.76 | PTGES (0.63) | PTGESMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |