Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11720909 | 0.96 | ALDH1A1 (0.54) | ESR1KDM4EALDH1A1SMN1; SMN2THRA | |
| SCHEMBL11714292 | 0.94 | ESR1 (0.54) | ESR1KDM4EALDH1A1SMN1; SMN2THRA | |
| SCHEMBL11715619 | 0.88 | ALDH1A1 (0.51) | KDM4EALDH1A1SMN1; SMN2THRATHRB | |
| SCHEMBL11720978 | 0.88 | ESR1 (0.58) | ESR1KDM4ESMN1; SMN2KMT2ALMNA | |
| SCHEMBL11716788 | 0.87 | ESR1 (0.48) | ESR1THRATHRBKMT2ALMNA | |
| SCHEMBL11716196 | 0.87 | ESR1 (0.44) | ESR1THRATHRBKMT2ALMNA | |
| SCHEMBL11717138 | 0.87 | THRA (0.49) | ESR1THRATHRBKMT2ALMNA | |
| SCHEMBL11719155 | 0.85 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2THRATHRB | |
| SCHEMBL11717402 | 0.84 | ESR1 (0.54) | ESR1SMN1; SMN2THRATHRBKMT2A | |
| SCHEMBL11714087 | 0.84 | ESR1 (0.57) | ESR1KDM4ESMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4010272-A | ANTHELMINTICALLY ACTIVE BASICALLY SUBSTITUTED 2-CARBALKOXY-AMINO-BENZIMIDAZOLYL-5(6)-PHENYL ETHERS AND -KETONES | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |