Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11735261 | 0.84 | KDM4E (0.48) | SMN1; SMN2KDM4ECHEK1LIMK1DYRK1A | |
| SCHEMBL11733455 | 0.84 | KDM4E (0.43) | SMN1; SMN2KDM4ECHEK1LIMK1DYRK1A | |
| SCHEMBL11738548 | 0.81 | TP53 (0.54) | SMN1; SMN2KDM4ETP53ALDH1A1TSHR | |
| SCHEMBL11734087 | 0.81 | KDM4E (0.54) | SMN1; SMN2KDM4ECHEK1LIMK1DYRK1A | |
| SCHEMBL11734966 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4ETP53ALDH1A1TSHR | |
| SCHEMBL24513313 | 0.71 | KDM4E (0.71) | SMN1; SMN2KDM4ETP53ALDH1A1GAA | |
| SCHEMBL11347014 | 0.70 | SMN1; SMN2 (0.39) | SMN1; SMN2KDM4ETP53KMOALDH1A1 | |
| SCHEMBL24513330 | 0.68 | NPC1 (0.49) | SMN1; SMN2KDM4ETP53KMT2AMAPT | |
| SCHEMBL11735893 | 0.68 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4ETP53ALDH1A1TSHR | |
| SCHEMBL23076418 | 0.66 | RAB9A (0.47) | SMN1; SMN2KDM4ETP53ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4041163-A | N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents | PFIZER INC. (US) | 1977-08-09 | — | — | US | disclosed |