Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 4/20 | 0.57 |
| ▸ | HTR1A | P08908 | 5/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11739332 | 0.88 | HTR2A (0.69) | MPOHTR1AHTR2ASLC6A4 | |
| SCHEMBL11739126 | 0.85 | HTR2A (0.60) | MPOHTR1AHTR2ASLC6A4 | |
| SCHEMBL11739185 | 0.83 | HTR2A (0.60) | HTR1AHTR2ASLC6A4HTR7 | |
| SCHEMBL11738116 | 0.82 | HTR6 (0.56) | MPOHTR6KCNH2SLC6A4 | |
| SCHEMBL11734599 | 0.79 | HTR2A (0.57) | HTR1AHTR2AHTR6KCNH2SLC6A4 | |
| SCHEMBL26508389 | 0.78 | MPO (0.67) | MPOHTR1AHTR2A | |
| SCHEMBL11785874 | 0.76 | KCNH2 (0.61) | HTR1AHTR2AHTR6KCNH2SLC6A4 | |
| SCHEMBL11734250 | 0.75 | HTR2A (0.65) | HTR1AHTR2A | |
| SCHEMBL11735694 | 0.74 | DRD2 (0.61) | HTR1AHTR2A | |
| SCHEMBL11733974 | 0.74 | HTR2A (0.60) | HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4031221-A | ANALGESICS, TRANQUILIZERS, INDOLE COMPOUNDS | AMERICAN HOECHST CORPORATION (US) | 1977-06-21 | — | — | US | disclosed |