Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11750266 | 0.89 | CACNA2D1 (0.46) | CACNA2D1SCN9ATSHRHSD17B10NPSR1 | |
| SCHEMBL11743527 | 0.86 | MAPT (0.38) | CACNA2D1HSD17B10NPSR1ALDH1A1KDM4E | |
| SCHEMBL11751106 | 0.78 | TP53 (0.45) | CACNA2D1HSD17B10NPSR1ALDH1A1KDM4E | |
| SCHEMBL11745628 | 0.78 | ALDH1A1 (0.45) | NPSR1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL11467756 | 0.76 | CACNA2D1 (0.44) | CACNA2D1NPSR1ALDH1A1MAPTTP53 | |
| SCHEMBL11745285 | 0.75 | NPSR1 (0.44) | CACNA2D1SCN9ANPSR1MAPTTP53 | |
| SCHEMBL11744357 | 0.74 | CACNA2D1 (0.40) | CACNA2D1MAPTTP53PTGS2LMNA | |
| SCHEMBL11741147 | 0.74 | MAPT (0.44) | CACNA2D1NPSR1ALDH1A1KDM4EHPGD | |
| SCHEMBL11477369 | 0.73 | CACNA2D1 (0.45) | CACNA2D1HSD17B10NPSR1ALDH1A1KDM4E | |
| SCHEMBL11827589 | 0.72 | ALOX5 (0.39) | CACNA2D1HSD17B10ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4008232-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
| US-3979516-A | Anti-inflammatory 3-amino-5,6-diaryl-1,2,4-triazines | ELI LILLY AND COMPANY (US) | 1976-09-07 | — | — | US | disclosed |
| US-3948894-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1976-04-06 | — | — | US | disclosed |