Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11751421 | 0.94 | LMNA (0.57) | LMNASMN1; SMN2PTGS2NPSR1RXFP1 | |
| SCHEMBL11753803 | 0.94 | LMNA (0.50) | LMNASMN1; SMN2PTGS2NPSR1RXFP1 | |
| SCHEMBL11748801 | 0.84 | ADORA1 (0.53) | LMNASMN1; SMN2PTGS2ADORA2ACYP1A2 | |
| SCHEMBL11755003 | 0.84 | PTGS2 (0.53) | LMNASMN1; SMN2PTGS2NPSR1RXFP1 | |
| SCHEMBL11751348 | 0.84 | PTGS2 (0.53) | LMNASMN1; SMN2PTGS2NPSR1RXFP1 | |
| SCHEMBL11753179 | 0.83 | ALDH1A1 (0.60) | LMNASMN1; SMN2PTGS2NPSR1RXFP1 | |
| SCHEMBL11753711 | 0.81 | RORB (0.47) | LMNASMN1; SMN2NPSR1CYP1A2CYP1A1 | |
| SCHEMBL9954155 | 0.79 | ADORA2A (0.48) | LMNASMN1; SMN2PTGS2NPSR1RXFP1 | |
| SCHEMBL11753624 | 0.79 | ADORA2A (0.50) | LMNASMN1; SMN2ADORA2ACYP1A2ALDH1A1 | |
| SCHEMBL11749855 | 0.78 | ADORA1 (0.53) | LMNASMN1; SMN2PTGS2NPSR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4051250-A | OXAZOLE, THIAZOLE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-27 | — | — | US | disclosed |
| US-3933840-A | ANTIPHLOGISTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1976-01-20 | — | — | US | disclosed |