Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL11837131 | 1.00 | ALDH1A1 (0.61) | ALDH1A1ALOX15KMT2AAPEX1AKR1C3 | |
| Phthalic Acid SCHEMBL33470 | 0.91 | ALDH1A1 (0.74) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL33468 | 0.91 | ALDH1A1 (0.74) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL14920338 | 0.89 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL1532704 | 0.89 | ALDH1A1 (0.78) | ALDH1A1ALOX15KMT2AAPEX1AKR1C3 | |
| Phthalic Acid SCHEMBL30182240 | 0.89 | ALDH1A1 (0.78) | ALDH1A1ALOX15KMT2AAPEX1AKR1C3 | |
| Phthalic Acid SCHEMBL5888909 | 0.89 | ALDH1A1 (0.78) | ALDH1A1ALOX15KMT2AAPEX1AKR1C3 | |
| Phthalic Acid SCHEMBL3671128 | 0.89 | ALDH1A1 (0.78) | ALDH1A1ALOX15KMT2AAPEX1AKR1C3 | |
| Phthalic Acid SCHEMBL11048689 | 0.88 | ALDH1A1 (0.47) | ALDH1A1ALOX15KMT2AAPEX1AKR1C3 | |
| Phthalic Acid SCHEMBL10894110 | 0.87 | ALDH1A1 (0.50) | ALDH1A1ALOX15KMT2AAPEX1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4003875-A | ULTRAVIOLET ABSORBERS | CIBA-GEIGY CORPORATION (US) | 1977-01-18 | — | — | US | disclosed |