Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913955 | 0.83 | ACHE (0.56) | PBRM1PTGS1ACHENPC1MITF | |
| SCHEMBL6154661 | 0.82 | PBRM1 (0.50) | PBRM1PTGS1ACHENPC1MITF | |
| SCHEMBL3260498 | 0.81 | PBRM1 (0.49) | PBRM1PTGS1ACHENPC1MITF | |
| SCHEMBL11768399 | 0.80 | CA12 (0.52) | ACHENPC1LMNAKDM4EALDH1A1 | |
| SCHEMBL28359889 | 0.79 | PBRM1 (0.59) | PBRM1PTGS1NPC1MITFLMNA | |
| SCHEMBL23217892 | 0.79 | PARP1 (0.52) | ACHENPC1ALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL633209 | 0.77 | PBRM1 (0.57) | PBRM1PTGS1NPC1MITFLMNA | |
| SCHEMBL3373649 | 0.77 | PBRM1 (0.57) | PBRM1PTGS1NPC1MITFLMNA | |
| SCHEMBL3801679 | 0.77 | ANPEP (0.43) | ACHECES2 | |
| SCHEMBL70367 | 0.77 | CES1 (0.56) | NPC1LMNAPOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3940407-A | β-Adrenergic blocking agents in the 1,2,3-thiadiazole series | SYNTEX (U.S.A.) INC. (US) | 1976-02-24 | — | — | US | disclosed |