Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.75 |
| ▸ | MAOB | P27338 | 1/20 | 0.75 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAT2A | P31153 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31500224 | 0.91 | MAOA (0.58) | MAOAMAOBMAPK1HTTNPC1 | |
| SCHEMBL9709249 | 0.90 | MAOA (0.72) | MAOAMAOBKDM1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL15124839 | 0.87 | MAOA (0.82) | MAOAMAOBKDM1AMAPK1HTT | |
| SCHEMBL27889436 | 0.87 | MAOA (1.00) | MAOAMAOBKDM1AMAPK1HTT | |
| SCHEMBL455949 | 0.87 | MAOA (1.00) | MAOAMAOBKDM1AMAPK1HTT | |
| SCHEMBL31500251 | 0.85 | MAOA (0.52) | MAOAMAOBMAPK1HTTNPC1 | |
| Hydrochloric Acid SCHEMBL28400797 | 0.84 | MAOA (0.95) | MAOAMAOBKDM1AMAPK1HTT | |
| SCHEMBL14951901 | 0.82 | MAOA (0.55) | MAOAMAOBKDM1AHTTSMN1; SMN2 | |
| SCHEMBL27961718 | 0.82 | MAOA (0.67) | MAOAMAOBKDM1AMAPTLMNA | |
| SCHEMBL11057550 | 0.82 | ACHE (0.67) | MAOAMAOBKDM1AHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3979515-A | THYMOANALEPTIC ACTIVITY | ROUSSEL-UCLAF (FR) | 1976-09-07 | — | — | US | disclosed |
| US-3957757-A | THYMOANALEPTICS | ROUSSEL-UCLAF (FR) | 1976-05-18 | — | — | US | disclosed |