Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.72 |
| ▸ | MAOB | P27338 | 1/20 | 0.72 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11780381 | 0.90 | MAOA (0.75) | MAOAMAOBPOLBKDM1AKDM4E | |
| SCHEMBL17423119 | 0.89 | POLB (0.55) | MAOAMAOBESR1ESR2POLB | |
| SCHEMBL31500251 | 0.88 | MAOA (0.52) | MAOAMAOBESR1ESR2POLB | |
| SCHEMBL15124839 | 0.85 | MAOA (0.82) | MAOAMAOBESR1ESR2POLB | |
| SCHEMBL455949 | 0.85 | MAOA (1.00) | MAOAMAOBPOLBKDM1AKDM4E | |
| SCHEMBL27889436 | 0.85 | MAOA (1.00) | MAOAMAOBPOLBKDM1AKDM4E | |
| SCHEMBL7795994 | 0.85 | ACHE (0.67) | MAOAMAOBESR1ESR2POLB | |
| SCHEMBL20535915 | 0.83 | KDM4E (0.62) | MAOAMAOBPOLBKDM4EALDH1A1 | |
| SCHEMBL9409823 | 0.83 | SLC2A1 (0.53) | MAOAMAOBESR1ESR2POLB | |
| Hydrochloric Acid SCHEMBL28400797 | 0.83 | MAOA (0.95) | MAOAMAOBESR1ESR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220306603-A1 | TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2022-09-29 | — | — | US | disclosed |
| WO-2020248075-A9 | TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2021-10-21 | — | — | WO | disclosed |
| WO-2020248075-A1 | TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2020-12-17 | — | — | WO | disclosed |
| US-10544100-B2 | Autophagy inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2020-01-28 | — | — | US | disclosed |
| US-20180290980-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2018-10-11 | — | — | US | disclosed |
| US-20170000784-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2017-01-05 | — | — | US | disclosed |
| US-20160137607-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2016-05-19 | — | — | US | disclosed |
| WO-2016005979-A1 | METHODS AND COMPOSITIONS FOR TREATING VIRAL INFECTIONS IN HONEYBEES | THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) (IL) | 2016-01-14 | — | — | WO | disclosed |
| US-9221760-B2 | Autophagy inhibitors | VAN ANDEL RESEARCH INSTITUTE (US) | 2015-12-29 | — | — | US | disclosed |
| WO-2015085229-A1 | AUTOPHAGY INHIBITORS | VAN ANDEL RESEARCH INSTITUTE (US) | 2015-06-11 | — | — | WO | disclosed |
| US-20140148451-A1 | Autophagy Inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2014-05-29 | — | — | US | disclosed |
| WO-2012154879-A2 | AUTOPHAGY INHIBITORS | VAN ANDEL RESEARCH INSTITUTE (US) | 2012-11-15 | — | — | WO | disclosed |
| EP-0471516-A1 | Tricyclic heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544100-B2 | Autophagy inhibitors | BECN1, ATG7, SQSTM1 | MAOA 2860/4885MAOB 2729/4885ESR1 4213/4885 |
| US-20170000784-A1 | Autophagy Inhibitors | BRAF, HRAS, NRAS | MAOA 3137/4885MAOB 4442/4885ESR1 4785/4885 |
| US-20140148451-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | MAOA 2860/4885MAOB 2729/4885ESR1 4213/4885 |
| US-20160137607-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | MAOA 2860/4885MAOB 2729/4885ESR1 4213/4885 |
| US-20220306603-A1 | TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF | ERCC4, ERCC1, ERCC2 | MAOA 4817/4885MAOB 4793/4885ESR1 69/4885 |
| US-20180290980-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | MAOA 2860/4885MAOB 2729/4885ESR1 4213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.