Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 13/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL269670 | 0.85 | KMT2A (0.46) | HCRTR1HCRTR2GRM6NPC1ALDH1A1 | |
| SCHEMBL269359 | 0.84 | GAA (0.49) | HCRTR1HCRTR2GRM6NPC1ALDH1A1 | |
| SCHEMBL8823173 | 0.80 | GRM6 (0.57) | GRM6NPC1ALDH1A1MAPTRAB9A | |
| Potassium Ion SCHEMBL11788185 | 0.79 | ALOX5 (0.56) | HCRTR1HCRTR2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL327675 | 0.75 | COMT (0.43) | ALDH1A1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL981602 | 0.74 | HCRTR1 (0.47) | HCRTR1HCRTR2KMT2ASLC9A1 | |
| SCHEMBL982568 | 0.74 | HCRTR1 (0.47) | HCRTR1HCRTR2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2094132 | 0.72 | POLB (0.41) | GRM6NPC1ALDH1A1SMN1; SMN2RAB9A | |
| Potassium Ion SCHEMBL11790309 | 0.71 | GRM6 (0.40) | GRM6NPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27485246 | 0.70 | GRM6 (0.44) | HCRTR1HCRTR2GRM6NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3935193-A | ANTIBIOTICS | TOYO JOZO KABUSHIKI KAISHA (JA) | 1976-01-27 | — | — | US | disclosed |