Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.55 |
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | HTR7 | P34969 | 4/20 | 0.55 |
| ▸ | HTR6 | P50406 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | UBE2N | P61088 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HEXA | P06865 | 1/20 | 0.49 |
| ▸ | HEXB | P07686 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11812529 | 0.84 | DRD2 (0.57) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL11803997 | 0.83 | ALDH1A1 (0.58) | KDM4ELMNAMAPTALDH1A1RAB9A | |
| SCHEMBL7971718 | 0.80 | CCR3 (0.66) | HTR1ADRD2SLC6A2SLC6A4 | |
| SCHEMBL11801164 | 0.79 | KDM4E (0.60) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL11801471 | 0.79 | KDM4E (0.61) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL11629904 | 0.79 | L3MBTL1 (0.47) | KDM4ELMNAMAPTALDH1A1HPGD | |
| SCHEMBL11807610 | 0.78 | KDM4E (0.58) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL6219793 | 0.78 | DRD2 (0.63) | HTR1ADRD2SLC6A2SLC6A4 | |
| SCHEMBL11813385 | 0.77 | KDM4E (0.51) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL11805624 | 0.77 | HTR7 (0.52) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3935227-A | ANTIDEPRESSANTS, ANTIANXIETY, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-27 | — | — | US | disclosed |