Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HTR5A | P47898 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13849307 | 0.92 | KDM1A (0.33) | KDM1ABRD4MAOAMAOB | |
| SCHEMBL6882141 | 0.85 | POLB (0.37) | KDM1ABRD4POLBPDK2PDK4 | |
| SCHEMBL13788693 | 0.78 | SLC6A2 (0.35) | KDM1ABRD4POLBGAAOPRM1 | |
| SCHEMBL13788728 | 0.77 | LMNA (0.36) | KDM1ABRD4POLBOPRM1ADRA2A | |
| SCHEMBL29384370 | 0.74 | PDK2 (0.42) | KDM1ABRD4POLBPDK2PDK4 | |
| SCHEMBL1031209 | 0.74 | PDK2 (0.42) | KDM1ABRD4POLBPDK2PDK4 | |
| SCHEMBL8524367 | 0.73 | KDM1A (0.33) | KDM1ABRD4OPRM1OPRL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2482151 | 0.72 | PDK2 (0.41) | KDM1ABRD4POLBPDK2PDK4 | |
| SCHEMBL7534912 | 0.71 | OPRM1 (0.36) | BRD4GAAOPRM1OPRL1ATM | |
| SCHEMBL11645508 | 0.70 | UTS2R (0.34) | OPRM1ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |
| US-3935199-A | ANALEPTIC | MEAD JOHNSON & COMPANY (US) | 1976-01-27 | — | — | US | disclosed |