Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.54 |
| ▸ | DRD2 | P14416 | 7/20 | 0.54 |
| ▸ | HTR2A | P28223 | 6/20 | 0.54 |
| ▸ | HTR6 | P50406 | 6/20 | 0.54 |
| ▸ | HTR7 | P34969 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | RAD52 | P43351 | 2/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11811153 | 0.87 | DRD2 (0.53) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11804698 | 0.86 | HTR1A (0.56) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11812209 | 0.82 | DRD2 (0.53) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11632571 | 0.81 | L3MBTL1 (0.43) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11801300 | 0.78 | HTR1A (0.64) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11814435 | 0.78 | HTR1A (0.57) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11813960 | 0.77 | KDM4E (0.57) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11810045 | 0.77 | KDM4E (0.59) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11806115 | 0.76 | KDM4E (0.56) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11811501 | 0.76 | MEN1 (0.50) | HTR1ADRD2HTR2AHTR6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3935227-A | ANTIDEPRESSANTS, ANTIANXIETY, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-27 | — | — | US | disclosed |