Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 5/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11825860 | 0.88 | MAT2A (0.48) | SMN1; SMN2PBRM1L3MBTL1BRD4HSD11B1 | |
| SCHEMBL11826249 | 0.85 | HSD11B1 (0.47) | SMN1; SMN2PBRM1L3MBTL1BRD4HSD11B1 | |
| SCHEMBL11826377 | 0.82 | PDE2A (0.47) | SMN1; SMN2BRD4HSD11B1ALDH1A1PDE2A | |
| SCHEMBL11819978 | 0.81 | MAPT (0.41) | SMN1; SMN2L3MBTL1BRD4HPGDALDH1A1 | |
| SCHEMBL11779422 | 0.77 | KDM4E (0.61) | SMN1; SMN2PBRM1L3MBTL1BRD4HPGD | |
| SCHEMBL11825891 | 0.75 | MAT2A (0.47) | SMN1; SMN2PBRM1L3MBTL1BRD4HSD11B1 | |
| SCHEMBL11834615 | 0.72 | MAT2A (0.64) | SMN1; SMN2PBRM1L3MBTL1BRD4HSD11B1 | |
| SCHEMBL11828073 | 0.67 | FNTA (0.46) | SMN1; SMN2PBRM1L3MBTL1BRD4HSD11B1 | |
| SCHEMBL1599263 | 0.67 | HPGD (0.41) | SMN1; SMN2PBRM1L3MBTL1BRD4HPGD | |
| SCHEMBL380188 | 0.66 | ALDH1A1 (0.58) | SMN1; SMN2HSD11B1HPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4000153-A | TRANQUILIZERS, SEDATIVES | THE UPJOHN COMPANY (US) | 1976-12-28 | — | — | US | disclosed |
| US-4000151-A | TRANQUILIZERS, SEDATIVES | THE UPJOHN COMPANY (US) | 1976-12-28 | — | — | US | disclosed |