Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IL6 | P05231 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11824349 | 0.84 | SYK (0.43) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11822532 | 0.83 | MAPT (0.46) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11827092 | 0.82 | NPC1 (0.44) | NPC1RAB9AKMT2AMAPTPTGS1 | |
| SCHEMBL11823327 | 0.80 | ALDH1A1 (0.46) | KMT2AMEN1MAPTPTGS1PTGS2 | |
| SCHEMBL11821784 | 0.80 | MAPT (0.48) | NPC1RAB9AKMT2AMEN1MAPT | |
| Hydrochloric Acid SCHEMBL11823944 | 0.79 | ALDH1A1 (0.45) | KMT2AMEN1MAPTPTGS1PTGS2 | |
| SCHEMBL11826476 | 0.77 | MAPT (0.35) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11823326 | 0.77 | EPHX2 (0.40) | RAB9AKMT2AMEN1MAPTEGFR | |
| SCHEMBL11825813 | 0.77 | PTGS1 (0.44) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL3452583 | 0.73 | PGK1 (0.33) | KMT2AMAPTPTGS1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3978057-A | HYPOTENSIVE AGENTS | SANDOZ, INC. (US) | 1976-08-31 | — | — | US | disclosed |