Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.36 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GOT1 | P17174 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11824349 | 0.87 | SYK (0.43) | MAPTNPC1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11823327 | 0.87 | ALDH1A1 (0.46) | MAPTLMNACYP1A2CYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL11823944 | 0.85 | ALDH1A1 (0.45) | MAPTLMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11827111 | 0.83 | NPC1 (0.40) | MAPTLMNANPC1CYP1A2CYP3A4 | |
| SCHEMBL11823326 | 0.83 | EPHX2 (0.40) | MAPTRAB9AGAAALDH1A1MEN1 | |
| SCHEMBL11821784 | 0.83 | MAPT (0.48) | MAPTLMNANPC1RAB9AKDR | |
| SCHEMBL11824162 | 0.79 | MAPT (0.52) | MAPTLMNANPC1CYP1A2CYP3A4 | |
| SCHEMBL11823547 | 0.77 | LMNA (0.43) | MAPTMKNK1LMNARAB9ASCN9A | |
| SCHEMBL11820367 | 0.73 | ALDH1A1 (0.36) | MAPTSYKGAAALDH1A1GOT1 | |
| SCHEMBL11827598 | 0.71 | ESR1 (0.36) | MAPTLMNAKDRFLT1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3978057-A | HYPOTENSIVE AGENTS | SANDOZ, INC. (US) | 1976-08-31 | — | — | US | disclosed |