Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11827598 | 0.91 | ESR1 (0.36) | MAPTGAANPSR1LMNAKMT2A | |
| SCHEMBL11827838 | 0.88 | MAPT (0.39) | MAPTGAANPSR1LMNATP53 | |
| SCHEMBL11825945 | 0.85 | MEN1 (0.37) | MAPTGAARAB9AEGFRKMT2A | |
| SCHEMBL11827111 | 0.77 | NPC1 (0.40) | MAPTGAANPC1RAB9AMAPKAPK2 | |
| SCHEMBL11827092 | 0.74 | NPC1 (0.44) | MAPTNPC1RAB9AMAPKAPK2LMNA | |
| SCHEMBL11824852 | 0.74 | KDM4E (0.36) | MAPTGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11834796 | 0.74 | ALDH1A1 (0.34) | MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11825801 | 0.73 | TDP1 (0.37) | MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11827166 | 0.68 | MAPT (0.42) | MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11884972 | 0.66 | RAB9A (0.43) | MAPTGAANPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3978057-A | HYPOTENSIVE AGENTS | SANDOZ, INC. (US) | 1976-08-31 | — | — | US | disclosed |