Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.43 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.65 |
| ▸ | RAD52 | P43351 | 2/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | PRKCB | P05771 | 1/20 | 0.55 |
| ▸ | PRKCA | P17252 | 1/20 | 0.55 |
| ▸ | PRKCH | P24723 | 1/20 | 0.55 |
| ▸ | PRKCI | P41743 | 1/20 | 0.55 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.55 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10884283 | 1.00 | DNM1 (0.65) | DNM1RAD52APAF1HSP90AA1PRKD3 | |
| Hydrochloric Acid SCHEMBL115731 | 1.00 | DNM1 (0.65) | DNM1RAD52APAF1HSP90AA1PRKD3 | |
| Hydrochloric Acid SCHEMBL28439271 | 1.00 | DNM1 (0.65) | DNM1RAD52APAF1HSP90AA1PRKD3 | |
| Hydrochloric Acid SCHEMBL10396250 | 1.00 | DNM1 (0.65) | DNM1RAD52APAF1HSP90AA1PRKD3 | |
| Hydrochloric Acid SCHEMBL116528 | 1.00 | DNM1 (0.65) | DNM1RAD52APAF1HSP90AA1PRKD3 | |
| SCHEMBL8855785 | 0.98 | DNM1 (0.64) | DNM1RAD52APAF1HSP90AA1PRKD3 | |
| SCHEMBL8855808 | 0.98 | DNM1 (0.64) | DNM1RAD52APAF1HSP90AA1PRKD3 | |
| Hydrochloric Acid SCHEMBL18191791 | 0.98 | DNM1 (0.61) | DNM1RAD52APAF1HSP90AA1PRKD3 | |
| SCHEMBL8855809 | 0.98 | DNM1 (0.64) | DNM1RAD52APAF1HSP90AA1PRKD3 | |
| SCHEMBL8855776 | 0.98 | DNM1 (0.64) | DNM1RAD52APAF1HSP90AA1PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9511008-B2 | Conditioning composition for keratin fibres and its use | KAO GERMANY GMBH (DE) | 2016-12-06 | — | — | US | claimed |
| US-9511008-B2 | Conditioning composition for keratin fibres and its use | KAO GERMANY GMBH (DE) | 2016-12-06 | — | — | US | disclosed |
| EP-2424489-B1 | CONDITIONING COMPOSITION FOR HAIR | KAO GERMANY GMBH (DE) | 2016-10-05 | — | — | EP | disclosed |
| EP-2563322-B1 | PROCESS FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO WASHING | KAO GERMANY GMBH (DE) | 2016-10-05 | — | — | EP | disclosed |
| US-8523953-B2 | Use of an amine and/or a quaternary ammonium compound for protecting colour of artificially coloured hair with respect to the washing and process therefore | KAO GERMANY GMBH (DE) | 2013-09-03 | — | — | US | disclosed |
| US-20130112217-A1 | CONDITIONING COMPOSITION FOR HAIR | KAO GERMANY GMBH (DE) | 2013-05-09 | — | — | US | disclosed |
| EP-2563322-A2 | USE OF AN AMINE AND/OR A QUATERNARY AMMONIUM COMPOUND FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO THE WASHING AND PROCESS THEREFORE | Kao Germany GmbH (DE) | 2013-03-06 | — | — | EP | disclosed |
| EP-2560607-A1 | CONDITIONING COMPOSITION FOR KERATIN FIBRES AND ITS USE | Kao Germany GmbH (DE) | 2013-02-27 | — | — | EP | disclosed |
| US-20130037045-A1 | USE OF AN AMINE AND/OR A QUATERNARY AMMONIUM COMPOUND FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO THE WASHING AND PROCESS THEREFORE | KAO GERMANY GMBH (DE) | 2013-02-14 | — | — | US | disclosed |
| US-20130032165-A1 | CONDITIONING COMPOSITION FOR KERATIN FIBRES AND ITS USE | KAO GERMANY GMBH (DE) | 2013-02-07 | — | — | US | disclosed |
| EP-2512421-A2 | CONDITIONING COMPOSITION FOR HAIR | Kao Germany GmbH (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2424489-A2 | CONDITIONING COMPOSITION FOR HAIR | KPSS-Kao Professional Salon Services GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |
| US-20120034182-A1 | CONDITIONING COMPOSITION FOR HAIR | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2012-02-09 | — | — | US | disclosed |
| WO-2011134848-A2 | USE OF AN AMINE AND/OR A QUATERNARY AMMONIUM COMPOUND FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO THE WASHING AND PROCESS THEREFORE | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2011-11-03 | — | — | WO | disclosed |
| EP-2382962-A1 | Use of an amine and/or a quaternary ammonium compound for protecting colour of artificially coloured hair with respect to the washing and process therefore | KPSS-Kao Professional Salon Services GmbH (DE) | 2011-11-02 | — | — | EP | disclosed |
| WO-2011131687-A1 | CONDITIONING COMPOSITION FOR KERATIN FIBRES AND ITS USE | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2011-10-27 | — | — | WO | disclosed |
| EP-2380555-A1 | Conditioning composition for keratin fibres and its use | KPSS-Kao Professional Salon Services GmbH (DE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2011072853-A2 | CONDITIONING COMPOSITION FOR HAIR | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2010124817-A2 | CONDITIONING COMPOSITION FOR HAIR | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130112217-A1 | CONDITIONING COMPOSITION FOR HAIR | AR, H1-4, H1-10 | ACHE 4472/4885DNM1 4579/4885RAD52 995/4885 |
| US-20130037045-A1 | USE OF AN AMINE AND/OR A QUATERNARY AMMONIUM COMPOUND FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO THE WASHING AND PROCESS THEREFORE | DOHH, HRH3, DAO | ACHE 3422/4885DNM1 2821/4885RAD52 682/4885 |
| US-20120034182-A1 | CONDITIONING COMPOSITION FOR HAIR | MSRB3, H1-4, OR10J3 | ACHE 4711/4885DNM1 3666/4885RAD52 1719/4885 |
| US-20130032165-A1 | CONDITIONING COMPOSITION FOR KERATIN FIBRES AND ITS USE | KRT18, CD69, KAT5 | ACHE 3917/4885DNM1 4528/4885RAD52 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.