Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MGAM | O43451 | 3/20 | 0.45 |
| ▸ | SI | P14410 | 3/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546109 | 0.83 | ADRA1D (0.65) | MAPTKMT2AGAAHTTMEN1 | |
| SCHEMBL11836368 | 0.80 | LMNA (0.69) | KMT2AHTTMEN1ALDH1A1MAPK1 | |
| SCHEMBL11841997 | 0.78 | ADRA2A (0.70) | KMT2AMEN1LMNAADRA2AADRA2B | |
| SCHEMBL11846843 | 0.78 | MAPT (0.74) | MAPTKMT2AGAAHTTMEN1 | |
| SCHEMBL11878846 | 0.75 | MAPT (0.60) | MAPTKMT2AGAAHTTMEN1 | |
| SCHEMBL11841817 | 0.71 | ADRA2A (0.60) | MAPTKMT2AGAAMEN1ALDH1A1 | |
| SCHEMBL11860457 | 0.70 | ADRA2A (0.59) | KMT2AMEN1LMNAADRA2AADRA2B | |
| SCHEMBL11840670 | 0.70 | SIRT1 (0.61) | MAPTKMT2ALMNAADRA2AADRA2B | |
| SCHEMBL11841837 | 0.70 | ADRA2A (0.56) | MAPTKMT2AHTTMEN1ALDH1A1 | |
| SCHEMBL28593688 | 0.70 | MEN1 (0.72) | MAPTKMT2AGAAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3997539-A | HYPOTENSIVE, TRANQUILIZER | AMERICAN HOECHST CORPORATION (US) | 1976-12-14 | — | — | US | claimed |
| US-3997539-A | HYPOTENSIVE, TRANQUILIZER | AMERICAN HOECHST CORPORATION (US) | 1976-12-14 | — | — | US | disclosed |