Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11843357 | 0.85 | ALDH1A1 (0.45) | LMNASMN1; SMN2CYP3A4ALOX15TDP1 | |
| SCHEMBL11841905 | 0.85 | TP53 (0.42) | LMNASMN1; SMN2TP53CYP3A4THRB | |
| SCHEMBL11856777 | 0.83 | MEN1 (0.58) | LMNASMN1; SMN2TDP1MAPTALDH1A1 | |
| SCHEMBL11848868 | 0.83 | TSHR (0.56) | LMNASMN1; SMN2CYP3A4ALOX15TDP1 | |
| SCHEMBL11852879 | 0.80 | MEN1 (0.56) | LMNASMN1; SMN2TP53CYP3A4THRB | |
| SCHEMBL28006672 | 0.77 | LMNA (0.56) | LMNASMN1; SMN2CYP3A4ALOX15MAPT | |
| SCHEMBL11846744 | 0.77 | ALDH1A1 (0.57) | SMN1; SMN2CYP3A4ALOX15TDP1MAPT | |
| SCHEMBL11847999 | 0.76 | ALPL (0.40) | LMNASMN1; SMN2TDP1MAPTALDH1A1 | |
| SCHEMBL11844362 | 0.76 | F2 (0.53) | LMNASMN1; SMN2TP53CYP3A4THRB | |
| SCHEMBL11772508 | 0.75 | LMNA (0.59) | LMNASMN1; SMN2TDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3996368-A | Anthelmintically active 2-carbalkoxyamino-5(6)-phenyl sulfonyloxy benzimidazoles | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-12-07 | — | — | US | disclosed |