Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 3/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP7 | P09237 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8975203 | 0.94 | LMNA (0.56) | LMNAMAPK1MMP13MMP12KDM4E | |
| SCHEMBL2563661 | 0.94 | LMNA (0.56) | LMNAMAPK1MMP13MMP12KDM4E | |
| SCHEMBL11835291 | 0.80 | MMP3 (0.47) | MMP13MMP12MMP3MMP2MMP1 | |
| SCHEMBL8993579 | 0.78 | LMNA (0.74) | LMNAMAPK1GAAMAPT | |
| SCHEMBL7564021 | 0.78 | LMNA (0.74) | LMNAMAPK1GAAMAPT | |
| SCHEMBL7564005 | 0.78 | LMNA (0.74) | LMNAMAPK1GAAMAPT | |
| SCHEMBL9251054 | 0.77 | MMP2 (0.46) | MMP13MMP12MMP3MMP2MMP1 | |
| SCHEMBL19002291 | 0.77 | GSK3B (0.44) | KDM4EGAAMAPTL3MBTL1CA1 | |
| SCHEMBL275597 | 0.77 | LMNA (0.79) | LMNAMAPK1L3MBTL1 | |
| SCHEMBL29001006 | 0.76 | HPGD (0.44) | MMP13MMP12MMP2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3941821-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYRETICS | WILLIAM H. RORER, INC. (US) | 1976-03-02 | — | — | US | disclosed |