Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11877772 | 0.75 | ALDH1A1 (0.50) | ALDH1A1NPSR1L3MBTL1TSHR | |
| SCHEMBL11850067 | 0.70 | TSHR (0.53) | DRD2SLC6A4ALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL11877009 | 0.70 | CASP3 (0.45) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL2665681 | 0.69 | L3MBTL1 (0.54) | DRD2SLC6A4ALDH1A1KDM4ELMNA | |
| SCHEMBL9625796 | 0.69 | L3MBTL1 (0.54) | DRD2SLC6A4ALDH1A1KDM4ELMNA | |
| SCHEMBL20534474 | 0.69 | DRD2 (0.66) | DRD2SLC6A4ALDH1A1NPSR1GAA | |
| SCHEMBL13925928 | 0.69 | L3MBTL1 (0.51) | DRD2SLC6A4ALDH1A1KDM4ELMNA | |
| SCHEMBL21311766 | 0.67 | DRD2 (0.43) | DRD2SLC6A4ALDH1A1KDM4ELMNA | |
| SCHEMBL24119280 | 0.67 | DRD2 (0.43) | DRD2SLC6A4ALDH1A1KDM4ELMNA | |
| SCHEMBL30259317 | 0.66 | IDO1 (0.47) | DRD2SLC6A4ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3984556-A | Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure | SANDOZ, INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3982000-A | Alkyl-substituted-tricyclic quinazolinones as bronchodilators | SANDOZ, INC. (US) | 1976-09-21 | — | — | US | disclosed |