SCHEMBL11875317

Cc1ccc(S(=O)(=O)OCC(=O)[C@@]23OC(C)(C)O[C@@H]2C[C@H]2[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]23C)cc1

nearest known ligand 0.74

Predicted protein targets (top 16)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1	P04150	12/20	0.74

▸	LMNA	P02545	5/20	0.74

▸	PGR	P06401	5/20	0.74

▸	HIF1A	Q16665	4/20	0.74

▸	AR	P10275	2/20	0.74

▸	ALDH1A1	P00352	1/20	0.74

▸	MEN1	O00255	1/20	0.74

▸	KMT2A	Q03164	1/20	0.74

▸	CYP3A4	P08684	2/20	0.72

▸	MAPT	P10636	1/20	0.72

▸	HSD17B10	Q99714	1/20	0.72

▸	TDP1	Q9NUW8	1/20	0.72

▸	KDM4E	B2RXH2	1/20	0.72

▸	MAPK1	P28482	1/20	0.72

▸	ESR1	P03372	2/20	0.55

▸	NR1I2	O75469	1/20	0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8205174	0.91	NR3C1 (0.82)	NR3C1LMNAPGRHIF1AAR
SCHEMBL8204288	0.88	NR3C1 (0.77)	NR3C1LMNAPGRHIF1AAR
SCHEMBL11864138	0.88	LMNA (0.72)	NR3C1LMNAPGRHIF1AAR
SCHEMBL13181632	0.87	NR3C1 (0.85)	NR3C1LMNAPGRHIF1AAR
SCHEMBL13596225	0.87	NR3C1 (0.85)	NR3C1LMNAPGRHIF1AAR
SCHEMBL16656251	0.87	NR3C1 (0.85)	NR3C1LMNAPGRHIF1AAR
SCHEMBL11870530	0.85	NR3C1 (0.55)	NR3C1LMNAPGRHIF1AAR
Fluocinonide SCHEMBL13568069	0.85	HIF1A (1.00)	NR3C1LMNAPGRHIF1AAR
SCHEMBL21795341	0.85	NR3C1 (0.83)	NR3C1LMNAPGRHIF1AAR
Fluocinonide SCHEMBL4262	0.85	HIF1A (1.00)	NR3C1LMNAPGRHIF1AAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-3975378-A	ANTIINFLAMMATORY	SYNTEX (U.S.A.) INC. (US)	1976-08-17	—	—	US	disclosed