Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.72 |
| ▸ | PGR | P06401 | 5/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 2/20 | 0.66 |
| ▸ | CNR1 | P21554 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | AR | P10275 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204639 | 0.91 | LMNA (0.80) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL11871915 | 0.90 | HIF1A (0.58) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL11054107 | 0.89 | HIF1A (0.58) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL11875317 | 0.88 | NR3C1 (0.74) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL13659970 | 0.87 | HIF1A (0.71) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL14114135 | 0.87 | LMNA (0.83) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL13524485 | 0.87 | LMNA (0.83) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL11862265 | 0.86 | NR3C1 (0.71) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL12087283 | 0.86 | HIF1A (0.70) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL15975096 | 0.85 | HIF1A (0.87) | LMNAHIF1ACYP3A4NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3975378-A | ANTIINFLAMMATORY | SYNTEX (U.S.A.) INC. (US) | 1976-08-17 | — | — | US | disclosed |