Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11881664 | 0.81 | P2RX7 (0.51) | P2RX7TSHRHTT | |
| SCHEMBL11871825 | 0.81 | CHRM1 (0.53) | P2RX7TSHRHTTALDH1A1CHRM5 | |
| SCHEMBL11873522 | 0.79 | TRPA1 (0.40) | P2RX7TSHR | |
| SCHEMBL11877099 | 0.78 | P2RX7 (0.53) | P2RX7TSHR | |
| SCHEMBL11849441 | 0.73 | TSHR (0.58) | TP53P2RX7PTGS1PTGS2TGM2 | |
| SCHEMBL15928248 | 0.71 | TGM2 (0.75) | PTGS1PTGS2TGM2ALDH1A1MAPT | |
| SCHEMBL10304923 | 0.69 | PTGS1 (0.65) | PTGS1PTGS2TGM2TSHRMAPT | |
| SCHEMBL29820186 | 0.69 | PTGS1 (0.65) | PTGS1PTGS2TGM2TSHRMAPT | |
| SCHEMBL17147697 | 0.68 | CYP3A4 (0.52) | TP53P2RX7PTGS1PTGS2TSHR | |
| SCHEMBL11802291 | 0.66 | CYP3A4 (0.53) | TP53P2RX7PTGS1PTGS2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3984556-A | Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure | SANDOZ, INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3982000-A | Alkyl-substituted-tricyclic quinazolinones as bronchodilators | SANDOZ, INC. (US) | 1976-09-21 | — | — | US | disclosed |